She plays an indirect role in the boss fight against the Blood Rose, where she summons Bloodsworn Simulacrums to attack the player. She appears as an apparition in various locations, referred to as 'Bloodsoaked Woman' in her text box. The Countess is encountered through the Dark Wood questline in Diablo Immortal.

'Care for a bloodbath?' (evil laughter).In Hell, she can drop up to Lo, though runes above Ist are very rare. In Nightmare, she can drop up to Ko, though runes above Io are very rare. The best odds of getting multiple runes comes from playing alone the more players there are in game, the lower her chance to drop more than one rune is. The best Runes possible improve on harder Difficulty levels. It is beneficial to repeatedly kill the Countess for Rune hunters as she has a very high chance to drop multiple runes even after the Forgotten Tower quest has been completed. On Hell, Countess is always immune to Cold and Fire. The Hell-difficulty Countess is the only monster to drop the Key of Terror in the game, which is used in the Pandemonium Event. The chest only opens upon killing The Countess for the first time.Д¬ompared to the other monsters around her, she has a higher chance to drop runes (see below). If she strays too far from her room, she does not trigger the event that unlocks the chest, so it's detrimental to lure her out. She is a Super Unique Dark Stalker found on the 5th level of the Forgotten Tower in the Black Marsh and must be killed in order to complete the associated quest. The Countess is the objective of The Forgotten Tower (quest) in Act IВ of Diablo II, which involves seeking the riches hidden underneath the remains of her tower. The Countess drove the Bloodsworn forward, but the hero(es) slew them, and confronted the Countess herself, slaying her in turn, and her Worldstone shard retrieved. The hero(es) later stormed the Forgotten Tower. However, it was not enough, and the Blood Rose was slain. From afar, she summoned simulacrums from the pool of blood the monstrosity resided in, to aid in its fight against the hero(es) that were attacking it. When Lakrii fed herself to the Blood Rose, her blood was apparently enough to finally fully revive the Countess. She ordered that they flee the Dark Wood before she decided they no longer could. She was defeated, but the Countess was unperturbed, stating that the blood of her servants returned to her upon their deaths, so that even her foes' victories hastened her return. The Countess reappeared to her foe(s) in the Fetid Swamp via some form of magical projection, where she ordered that Vassarici kill them. Yet even this was not enough to restore the Countess fully, and she ordered the Bloodsworn to hasten their efforts, lest they lose her favor. The Bloodsworn themselves razed the town of Blackstone to the ground, gathered the blood of every man, woman, and child, and through some kind of ritual, infused their mistress with it. As long as it continued to feed her blood, the Countess would not die. The roots of the Blood Rose ran through the Dark Wood, feeding her with blood spilt within the forest. The Bloodsworn set about collecting blood for her in an effort to restore her to her former glory.

Furthermore, a Worldstone shard came into the Countess's possession, which she wore around her neck. Six years later, the Countess was resurrected by a group of cultists called the Bloodsworn, who served as her followers. The sacrifice I have planned will provide more than enough. Hasten your efforts, lest you lose my favor.' The blood of every man, woman, and child in Blackstone runs through your veins.' However, she was slain, and they helped themselves to the treasures within. In 1264, a group of adventurers entered the Countess's tower, only to encounter the Countess herself. It is believed that her fortune was divided up among the clergy, but that some of it remained in the tower. It is said that she bathed in the 'rejuvinating blood of a hundred virgins', but was buried alive. The Countess once ruled from a castle in the Black Marsh. Rising over the buried dungeons in that god-forsaken wilderness, a solitary tower, like some monument to Evil, is all that remains.' And her castle in which so many cruel deeds took place fell rapidly into ruin. 'And so it came to pass that the Countess, who once bathed in the rejuvenating blood of a hundred virgins, was buried alive.

Diablo 2 countess rune drops